Xiao-Kun Zhang, Ph.D.

The Burnham Institute for Medical Research
email: xzhang@sbpdiscovery.org

Grants

Sulindac-derived compounds for breast cancer therapy 2014 (Cycle 20)
IDEA (Innovative, Developmental, and Exploratory Awards) 20IB-0138 $292,498
Nur77-derived Peptides as a Novel Breast Cancer Therapy 2006 (Cycle 12)
IDEA (Innovative, Developmental, and Exploratory Awards) 12IB-0168 $286,108
TR3-based Peptides for Apoptosis in Breast Cancer 2002 (Cycle VIII)
STEP Award 8WB-0179 $380,825
Breast Cancer Chemoprevention by Retinoids 1997 (Cycle III)
RFA (Request for Applications) 3PB-0018 $967,300


Targeting truncated RXRá for cancer therapy
  Periodical: Acta Biochimica et Biophysica Sinica
  Author(s): Zhang, XK., Zhou, H., and Su, Y.
  Yr: 2016 Vol: 48 Nbr: Pgs: 49-59
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
Homokiol sensitizes breast cancer cells to TNFinduction of apoptosis by inhibiting Nur77 expression
  Periodical: British Journal of Pharmacology
  Author(s): Xie L, Jiang F, Zhang X, Alitongbieke G, Shi X, Meng M, Xu Y, Ren A, Wang J, Cai L, et al.
  Yr: 2016 Vol: 173 Nbr: Pgs: 344-356
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site
  Periodical: Bioorganic & Medicinal Chemistry
  Author(s): Xu D, Guo S, Chen Z, Bao Y, Huang F, Xu D, Zhang X, Zeng Z, Zhou H, Zhang X, Su Y
  Yr: 2016 Vol: 26 Nbr: 16 Pgs: 3846-9
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
NSC-640358 acts as RXRá ligand to promote TNFá-mediated apoptosis of cancer cell
  Periodical: Protein & Cell
  Author(s): Chen, F., Chen, J., Lin, J., Cheltsov, AV., Xu, L., Chen, Y., Zeng, Z., Chen, L., et al.
  Yr: 2015 Vol: 6 Nbr: Pgs: 654-666
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
Nitrostyrene Derivatives Act as RXRá Ligands to Inhibit TNFá Activation of NF- kB
  Periodical: Cancer Research
  Author(s): Zeng Z, Sun Z, Huang M, et al.
  Yr: 2015 Vol: Mar 20 Nbr: Pgs:
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
Induction of Nur77-dependent apoptotic pathway by a coumari derivative through activation of JNk and p38 MAPK. PMCID: PMC4247515.
  Periodical: Carcinogenesis
  Author(s): Zhou Y, Zhao W, Xie G, et al.
  Yr: 2014 Vol: 35 Nbr: Pgs: 2660-9
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
Regulation of the nongenomic actions of retinoid X receptor-a by targeting the coregulator-binding sites - doi: 10.1038/aps.2014.109
  Periodical: Acta Pharmacol Sin
  Author(s): Zhang, X-k, Su Y, Chen, L, Chen, F, Liu, J, Zhou, H.
  Yr: 2014 Vol: Nbr: Pgs:
  Associated Grant: Sulindac-derived compounds for breast cancer therapy
 
RXR agonists inhibit high-glucose-induced oxidative stress by repressing PKC activity in human endothelial cells.
  Periodical: Free Radical Biology and Medicine
  Author(s): Chai D, Wang B, Shen L, Pu J, Zhang XK, He B
  Yr: 2008 Vol: 44 Nbr: 7 Pgs: 1334-47
  Associated Grant: Nur77-derived Peptides as a Novel Breast Cancer Therapy
 
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer
  Periodical: Cancer Cell
  Author(s): Kolluri SK, et al, and Zhang XK
  Yr: 2008 Vol: 14 Nbr: 4 Pgs: 285-98
  Associated Grant: Nur77-derived Peptides as a Novel Breast Cancer Therapy
 
Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues.
  Periodical: Cancer Research
  Author(s): Liu J, et al, and Zhang XK, Zeng JZ
  Yr: 2008 Vol: 68 Nbr: 21 Pgs: 8871-80
  Associated Grant: Nur77-derived Peptides as a Novel Breast Cancer Therapy
 
Targeting Nur77 translocation
  Periodical: Expert Opinion on Therapeutic Targets
  Author(s): Zhang XK
  Yr: 2007 Vol: 11 Nbr: 1 Pgs: 69-79
  Associated Grant: Nur77-derived Peptides as a Novel Breast Cancer Therapy
 
p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction.
  Periodical: Oncogene
  Author(s): Moll UM, Marchenko N, Zhang XK
  Yr: 2006 Vol: 25 Nbr: 34 Pgs: 4725-43
  Associated Grant: Nur77-derived Peptides as a Novel Breast Cancer Therapy
 
Retinoid X receptor regulates Nur77/TR3-dependent apoptosis [corrected] by modulating its nuclear export and mitochondrial targeting.
  Periodical: European Jounal of Publc Health
  Author(s): Bingzhen Lin, Young-hoon Han, Marcia I. Dawson, Xi Zhang, F Lin Xihua Cao, Wen Liu,
  Yr: 2004 Vol: 24 Nbr: 22 Pgs: 9705-9725
  Associated Grant: TR3-based Peptides for Apoptosis in Breast Cancer
 
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3.
  Periodical: Cell
  Author(s): Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK.
  Yr: 2004 Vol: 116 Nbr: Pgs: 527-540
  Associated Grant: TR3-based Peptides for Apoptosis in Breast Cancer
 
Cytochrome c release and apoptosis induced by mitochondrial targeting of orphan receptor TR3
  Periodical: Science
  Author(s): Li H, Kolluri SK, Gu J, Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie, et al
  Yr: 2000 Vol: 289 Nbr: 5482 Pgs: 1159-64
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Unique anti-activator protein-1 activity of retinoic acid receptor B1
  Periodical: Cancer Research
  Author(s): Lin F, Xiao D, Kolluri SK, Zhang X.
  Yr: 2000 Vol: 60 Nbr: 12 Pgs: 3271-80
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells
  Periodical: Molecular and Cellular Biology
  Author(s): Lin B, Chen GQ, Xiao D, Kolluri SK, Cao X, Su H, Zhang XK
  Yr: 2000 Vol: 20 Nbr: 3 Pgs: 957-70
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells
  Periodical: Molecular and Cellular Biology
  Author(s): Lin B, Chen GQ, Xiao D, Kolluri SK, Cao X, Su H, Zhang XK
  Yr: 2000 Vol: 20 Nbr: 3 Pgs: 957-70
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Resistance of HBL100 human breast epithelial cells to vitamin D action
  Periodical: Carcinogenesis
  Author(s): Agadir A, Lazzaro G, Zheng Y, Zhang XK, Mehta R
  Yr: 1999 Vol: 20 Nbr: 4 Pgs: 577-82
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells
  Periodical: Journal of Biological Chemistry
  Author(s): Li Y, Hashimoto Y, Agadir A, Kagechika H, Zhang X
  Yr: 1999 Vol: 274 Nbr: 22 Pgs: 15360-6
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Differential effect of retinoic acid on growth regulation by phorbol ester in human cancer cell lines
  Periodical: Journal of Biological Chemistry
  Author(s): Agadir A, Chen G, Bost F, Li Y, Mercola D, Zhang X
  Yr: 1999 Vol: 274 Nbr: 42 Pgs: 29779-85
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias
  Periodical: Journal of Medicinal Chemistry
  Author(s): Muccio DD, Brouillette WJ, Breitman TR, Taimi M, Emanuel PD, Zhang X, Chen G, Sani, et al
  Yr: 1998 Vol: 41 Nbr: 10 Pgs: 1679-87
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Effects of trans-retinoic acid, 9-cis-retinoic acid, 1alpha,25-(dihydroxy)vitamin D3 and a novel apoptosis-inducing retinoid on breast cancer and endothelial cell growth.
  Periodical: Cancer Letters
  Author(s): Dawson MI, Chao WR, Hobbs PD, Zhang XK
  Yr: 1998 Vol: 133 Nbr: 1 Pgs: 1-8
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
  Periodical: Journal of Biological Chemistry
  Author(s): Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK
  Yr: 1998 Vol: 273 Nbr: 27 Pgs: 16985-92
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
BAG-1 binds to and inhibits the retinoic acid receptor (RAR): implications for mechanisms of retinoid resistance in cancer
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Liu R, Zheng Y, Takayama S, Chen G-q, Knee D, Foresch B, Kitada B, and Zhang X-k, et al
  Yr: 1998 Vol: 39 Nbr: Pgs: 274
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Inhibition of trans-RA-resistant human breast cancer cell growth by retinoid X receptor-selective retinoids
  Periodical: Keystone symposium on the Nuclear Receptor Gene Family
  Author(s): Lin B, Wu Q, Dawson, MI, Zheng Y, and Ahang X-k
  Yr: 1998 Vol: Nbr: Pgs:
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Retinyl methyl ether down-regulates AP-1 transcriptional activation in breast cancer cells
  Periodical: Cancer Research
  Author(s): Agadir A, Shealy YF, Hill DL, and Zhang X-K
  Yr: 1997 Vol: 57 Nbr: 16 Pgs: 3444-50
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization
  Periodical: Embo Journal
  Author(s): Wu Q, Li Y, Liu R, Agadir A, Lee M-O, et al.
  Yr: 1997 Vol: 16 Nbr: Pgs: 1656-1669
  Associated Grant: Breast Cancer Chemoprevention by Retinoids
 
Nuclear export and mitochondrial targeting of Nur77/TR3 are regulated by retinoid X receptor.
  Periodical: Molecular and Cellular Biology
  Author(s): Cao X, Liu W, Lin F, Kumar S, Lin B, Han Y, Dawson MI, and Zhang XK
  Yr: 0 Vol: Nbr: Pgs:
  Associated Grant: TR3-based Peptides for Apoptosis in Breast Cancer