Brunhilde Felding, Ph.D.

Scripps Research Institute
email: brunie@scripps.edu

Grants

Host Hypoxia to Treat Breast Cancer Brain Metastasis 2012 (Cycle 18)
IDEA (Innovative, Developmental, and Exploratory Awards) 18IB-0022 $284,250
Combating Breast Cancer with the Wellderly Immune Repertoire 2011 (Cycle 17)
IDEA-competitive renewal 17NB-0058 $473,750
Targeting Brain Metastasis with a Cell-based Approach 2010 (Cycle 16)
IDEA (Innovative, Developmental, and Exploratory Awards) 16IB-0030 $284,354
Inhibiting Breast Cancer Brain Metastasis with Cilengitide 2010 (Cycle 16)
IDEA (Innovative, Developmental, and Exploratory Awards) 16IB-0052 $284,435
Combating Breast Cancer with the Wellderly Immune Repertoire 2009 (Cycle 15)
IDEA (Innovative, Developmental, and Exploratory Awards) 15IB-0050 $284,718
Neural Stem Cell Therapy for Breast Cancer Brain Metastases 2007 (Cycle 13)
IDEA-competitive renewal 13NB-0180 $419,400
Inhibition of Brain Metastases in Breast Cancer 2006 (Cycle 12)
IDEA-competitive renewal 12NB-0176 $464,750
Neural Stem Cell Therapy for Breast Cancer Brain Metastases 2006 (Cycle 12)
IDEA (Innovative, Developmental, and Exploratory Awards) 12IB-0122 $302,085
Inhibition of Brain Metastases in Breast Cancer 2005 (Cycle 11)
IDEA (Innovative, Developmental, and Exploratory Awards) 11IB-0077 $278,850
Stem Cells in Breast Cancer Metastasis 2004 (Cycle 10)
SPRC (Scientific Perspectives Research Collaboration) Full Research Awards 10YB-0202 $621,289
Breast Cancer Cell Binding to the Endothelium 1999 (Cycle V)
IDEAS II 5JB-0143 $326,892


Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
  Periodical: Journal of Clinical Investigation
  Author(s): Santidrian AF, Matsuno-Yagi A., Rittland M., Seo BB., Leboeuf SE, Gay LJ, et al.
  Yr: 2013 Vol: 123 Nbr: 3 Pgs: 1068-1081
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Axup JY, Bajjuri KM, Ritland M, Hutchins BM, Kim CH, Kazane SA, Halder R, Forsyth JS et al
  Yr: 2012 Vol: 109 Nbr: 40 Pgs: 16101-6
  Associated Grant: Host Hypoxia to Treat Breast Cancer Brain Metastasis
 
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Jun Y, Axup JY, Bajjuri KM, Ritland M.et al.
  Yr: 2012 Vol: 109 Nbr: 40 Pgs: 16101-6
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Contribution of platelets to tumour metastasis.
  Periodical: Nature Reviews. Cancer
  Author(s): Gay LJ, Felding-Habermann B.
  Yr: 2011 Vol: 11 Nbr: 2 Pgs: 123-34
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells.
  Periodical: Journal of Neurooncology
  Author(s): Loger M, Lee H, Forsyth JS, Felding-Habermann B
  Yr: 2011 Vol: 104 Nbr: 3 Pgs: 689-696
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Platelets alter tumro cell attributes to propel metastasis: programming in transit.
  Periodical: Cancer Cell
  Author(s): Gay LJ, Felding-Habermann B.
  Yr: 2011 Vol: 20 Nbr: 5 Pgs: 553-554
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Site-specific coupling and setrically controlled formation of multimeric antibody fab fragments with unnatural amino acids.
  Periodical: Journal of Molecular Biology
  Author(s): Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Schultz PG, Smider VV
  Yr: 2011 Vol: 406 Nbr: 4 Pgs: 595-603
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Selective formation of covalent protein heterodimers with unnatural amino acids.
  Periodical: Chemistry and Biology
  Author(s): Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Smider VV, Schultz PG
  Yr: 2011 Vol: 18 Nbr: 3 Pgs: 299-303
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Chemically programmed antibodies targeting multiple av integrins and their effects on tumor-related functions in vitro.
  Periodical: Bioconjugate Chemistry
  Author(s): Goswami RK, Bajjuri KM, Forsyth JS, Das S, Hassenpflug W, et al.
  Yr: 2011 Vol: 22 Nbr: 8 Pgs: 1535-1544
  Associated Grant: Combating Breast Cancer with the Wellderly Immune Repertoire
 
Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro.
  Periodical: Bioconjugate Chemistry
  Author(s): Goswami RK, et al and Felding-Habermann B
  Yr: 2011 Vol: 22 Nbr: 8 Pgs: 1535-44
  Associated Grant: Neural Stem Cell Therapy for Breast Cancer Brain Metastases
 
Selective formation of covalent protein heterodimers with an unnatural amino acid.
  Periodical: Chemistry and Biology
  Author(s): Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Smider VV, Schultz PG
  Yr: 2011 Vol: 18 Nbr: 3 Pgs: 299-303
  Associated Grant: Inhibiting Breast Cancer Brain Metastasis with Cilengitide
 
Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells.
  Periodical: Journal of Neurooncology
  Author(s): Lorger M, Lee H, Forsyth JS, Felding-Habermann B
  Yr: 2011 Vol: 104 Nbr: 3 Pgs: 689-96
  Associated Grant: Inhibiting Breast Cancer Brain Metastasis with Cilengitide
 
Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids.
  Periodical: Journal of Molecular Biology
  Author(s): Hutchins BM, Kazane SA, Staflin K, Forsyth JS, Felding-Habermann B, Schultz PG, Smider VV
  Yr: 2011 Vol: 406 Nbr: 4 Pgs: 595-603
  Associated Grant: Inhibiting Breast Cancer Brain Metastasis with Cilengitide
 
Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells.
  Periodical: Journal of Neurooncology
  Author(s): Lorger M, Lee H, Forsyth JS, Felding-Habermann B
  Yr: 2011 Vol: 104 Nbr: 3 Pgs: 689-96
  Associated Grant: Targeting Brain Metastasis with a Cell-based Approach
 
Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis.
  Periodical: American Journal of Pathology
  Author(s): Lorger M, Felding-Habermann B
  Yr: 2010 Vol: 176 Nbr: 6 Pgs: 2958-71
  Associated Grant: Neural Stem Cell Therapy for Breast Cancer Brain Metastases
 
Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.
  Periodical: Clinical & Experimental Metastasis
  Author(s): Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M and Felding-Habermann B
  Yr: 2010 Vol: 27 Nbr: 4 Pgs: 217-31
  Associated Grant: Neural Stem Cell Therapy for Breast Cancer Brain Metastases
 
Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis.
  Periodical: American Journal of Pathology
  Author(s): Lorger M, Felding-Habermann B
  Yr: 2010 Vol: Nbr: Pgs: ePub
  Associated Grant: Inhibition of Brain Metastases in Breast Cancer
 
Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.
  Periodical: Clinical & Experimental Metastasis
  Author(s): Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, and Felding-Habermann B
  Yr: 2010 Vol: Nbr: Pgs: Mar 12, ePub
  Associated Grant: Inhibition of Brain Metastases in Breast Cancer
 
Maintaining and Engineering Neural Stem Cells for Delivery of Genetically Encoded Therapy to Brain Tumors
  Periodical: Methods in Molecular Biology
  Author(s): Katz J, Krueger J, Felding-Habermann B, Snyder EY
  Yr: 2009 Vol: 568 Nbr: Pgs: 249-59
  Associated Grant: Inhibition of Brain Metastases in Breast Cancer
 
Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Lorger M, Krueger JS, O'Neal M, Staflin K, Felding-Habermann B
  Yr: 2009 Vol: 106 Nbr: 26 Pgs: 10666-71
  Associated Grant: Inhibition of Brain Metastases in Breast Cancer
 
Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Lorger M, Krueger JS, O'Neal M, Staflin K, Felding-Habermann B
  Yr: 2009 Vol: 106 Nbr: 26 Pgs: 10666-71
  Associated Grant: Neural Stem Cell Therapy for Breast Cancer Brain Metastases
 
Maintaining and engineering neural stem cells for delivery of genetically encoded therapy to brain tumors.
  Periodical: Methods in Molecular Biology
  Author(s): Katz J, Krueger J, Felding-Habermann B, Snyder EY.
  Yr: 2009 Vol: 568 Nbr: Pgs: 249-59
  Associated Grant: Neural Stem Cell Therapy for Breast Cancer Brain Metastases
 
The biology of metastasis to a sanctuary site.
  Periodical: Clinical Cancer Research
  Author(s): Palmieri D, Chambers AF, Felding-Habermann B, Huang S, Steeg PS.
  Yr: 2007 Vol: 13 Nbr: 6 Pgs: 1656-62
  Associated Grant: Stem Cells in Breast Cancer Metastasis
 
Adaptation of energy metabolism in breast cancer brain metastases.
  Periodical: Cancer Research
  Author(s): Chen EI, et al, Yates JR 3rd, and Felding-Habermann B
  Yr: 2007 Vol: 67 Nbr: 4 Pgs: 1472-86
  Associated Grant: Stem Cells in Breast Cancer Metastasis
 
The biology of metastasis to a sanctuary site.
  Periodical: Clinical Cancer Research
  Author(s): Palmieri D, Chambers AF, Felding-Habermann B, Huang S, Steeg PS.
  Yr: 2007 Vol: 13 Nbr: 6 Pgs: 1656-62
  Associated Grant: Inhibition of Brain Metastases in Breast Cancer
 
Adaptation of energy metabolism in breast cancer brain metastases.
  Periodical: Cancer Research
  Author(s): Chen EI, et al, and Felding-Habermann B
  Yr: 2007 Vol: 67 Nbr: 4 Pgs: 1472-86
  Associated Grant: Inhibition of Brain Metastases in Breast Cancer
 
Large scale protein profiling by combination of protein fractionation and multidimensional protein identification technology (MudPIT).
  Periodical: Molecular and Cellular Proteomics
  Author(s): Chen EI, Hewel J, Felding-Habermann B, Yates JR 3rd.
  Yr: 2006 Vol: 5 Nbr: 1 Pgs: 53-6
  Associated Grant: Stem Cells in Breast Cancer Metastasis
 
Tumor cell-platelet interactions in metastatic disease
  Periodical: Haemostasis
  Author(s): Felding-Habermann B
  Yr: 2001 Vol: 31(Suppl) Nbr: Pgs: 55-58
  Associated Grant: Breast Cancer Cell Binding to the Endothelium
 
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.
  Periodical: Journal of Clinical Investigation
  Author(s): Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, LeBoeuf SE, Gay LJ, Yagi T, Felding-Habe
  Yr: 123 Vol: Nbr: 1068-81 Pgs:
  Associated Grant: Host Hypoxia to Treat Breast Cancer Brain Metastasis