Thea Tlsty, Ph.D.

University of California, San Francisco
email: Ttlsty@itsa.ucsf.edu

Grants

Preventing Tumor Progression in Women with High-Risk DCIS 2016 (Cycle 22)
Translational Research Awards 22OB-0032 $956,774
Using Epigenetic Changes to Stratify DCIS Biopsies 2012 (Cycle 18)
Translational Research Awards 18OB-0060 $750,000
Stratifying DCIS Biopsies for Risk of Future Tumor Formation 2008 (Cycle 14)
Translational Research Awards 14OB-0165 $750,000
Breast Cancer Risk Associated with High Mammographic Density 2005 (Cycle 11)
IDEA (Innovative, Developmental, and Exploratory Awards) 11IB-0039 $148,163
Early Transitions in Breast Cancer 2003 (Cycle IX)
STEP Award 9WB-0107 $199,424
Breast Stromal Genes Act as Early Markers of Malignancy 2002 (Cycle VIII)
TRC (Translational Research Collaboration) Full Research Awards 8EB-0106 $249,624
Breast Stromal Genes Act as Early Markers of Malignancy 2002 (Cycle VIII)
TRC (Translational Research Collaboration) Full Research Awards 8EB-1106 $398,072


Biomarker expression and risk of subsequent tumors after initial ductal carcinoma in situ diagnosis.
  Periodical: Journal of the National Cancer Institute
  Author(s): Kerlikowske K, Molinaro AM, Gauthier ML, and Tlsty, TD
  Yr: 2010 Vol: 102 Nbr: 9 Pgs: 627-37
  Associated Grant: Stratifying DCIS Biopsies for Risk of Future Tumor Formation
 
Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications.
  Periodical: Cancer Prevention Research
  Author(s): Berman HK, Gauthier ML, Tlsty TD
  Yr: 2010 Vol: 3 Nbr: 5 Pgs: 579-87
  Associated Grant: Stratifying DCIS Biopsies for Risk of Future Tumor Formation
 
DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.
  Periodical: Cancer Prevention Research
  Author(s): Fordyce C, Fessenden T, Pickering C, Jung J, Singla V, Berman H, Tlsty T
  Yr: 2010 Vol: 3 Nbr: 2 Pgs: 190-201
  Associated Grant: Stratifying DCIS Biopsies for Risk of Future Tumor Formation
 
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.
  Periodical: Breast Cancer Research
  Author(s): Dumont N, Crawford YG, Sigaroudinia M, Nagrani SS, Wilson MB, Buehring GC and Tlsty TD
  Yr: 2009 Vol: 11 Nbr: 6 Pgs: R87
  Associated Grant: Stratifying DCIS Biopsies for Risk of Future Tumor Formation
 
Abrogated Response to Cellular Stress Identifies DCIS Associated with SubsequentTumorEvents and Defines Basal-like BreastTumors
  Periodical: Cancer Cell
  Author(s): Gauthier, M.L., Berman, H.K., Miller, C., Kozakeiwicz, K., Chew, K. et al.
  Yr: 2007 Vol: 12 Nbr: Pgs: 479-491
  Associated Grant: Early Transitions in Breast Cancer
 
Lysyl oxidase is essential for hypoxia-induced metastasis
  Periodical: Nature
  Author(s): Erler JT, Bennewith KL, Nicolau M, Dornhofer N, Kong C, Le QT, Chi JT, Jeffrey SS et al.
  Yr: 2006 Vol: 440 Nbr: 7088 Pgs: 1222-6
  Associated Grant: Breast Stromal Genes Act as Early Markers of Malignancy
 
p38 regulates COX-2 in human mammary epithelial cells and is activated in pre-malignant tissue.
  Periodical: Cancer Research
  Author(s): Gauthier, M.L., Pickering, C.R., Miller, C. J., Chew, K.L., Fordyce, C.A., et al.
  Yr: 2005 Vol: 65 Nbr: Pgs: 1793-9
  Associated Grant: Early Transitions in Breast Cancer
 
Histologically normal human mammary epithelia with silenced p16ink4A overexpress COX-2, promoting a malignant program
  Periodical: Cancer Cell
  Author(s): Crawford, Y., Gauthier, M.L., Joubel, A., Mantel, K., Afshari, C.A., Tlsty, T.
  Yr: 2004 Vol: 5 Nbr: Pgs: 263-73
  Associated Grant: Early Transitions in Breast Cancer
 
Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.
  Periodical: Journal of Mammary Gland Biology and Neoplasia
  Author(s): Tlsty, T.D., Crawford, Y.G., Holst, C.R., Fordyce, C.A., Zhang, J., McDermott, K., et al.
  Yr: 2004 Vol: 9 Nbr: Pgs: 263-74
  Associated Grant: Early Transitions in Breast Cancer