Gary Firestone, Ph.D.

University of California, Berkeley
email: glfire@berkeley.edu

Grants

Artemisinin Disrupts Estrogen Receptor-Alpha and Cell Growth 2006 (Cycle 12)
IDEA (Innovative, Developmental, and Exploratory Awards) 12IB-0166 $100,000
Novel I3C Regulated Cell Cycle Factor in Breast Cancer Cells 2003 (Cycle IX)
STEP Award 9WB-0148 $150,000
Dietary Indole Effect on Estrogen Urinary Metabolites 2001 (Cycle VII)
TRC (Translational Research Collaboration) Pilot Awards 7DB-0010 $89,925
Indole Derivatives as Novel Breast Cancer Therapeutics 1999 (Cycle V)
IDEAS II 5JB-0016 $150,000
Dietary Indole Inhibition of Breast Cancer 1997 (Cycle III)
IDEA (Innovative, Developmental, and Exploratory Awards) 3IB-0110 $150,000


Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells.
  Periodical: Carcinogenesis
  Author(s): Sundar SN, Marconett CN, Doan VB, Willoughby JA Sr, Firestone GL
  Yr: 2008 Vol: 29 Nbr: 122252-8 Pgs:
  Associated Grant: Artemisinin Disrupts Estrogen Receptor-Alpha and Cell Growth
 
Indole-3-Carbionl (I3C) Inhibits Cyclin Dependent Kinase-2 Function in Human Breast Cancer Cells by Regulating the Size Distribution, Associated Cyclin E Forms and Subcellular Localization of the CDK2 Protein Complex
  Periodical: Journal of Biological Chemistry
  Author(s): Garcia H.H., Brar G.A., Nguyen D.H.H., Bjeldanes, L.F., and Firestone G.L.
  Yr: 2005 Vol: 280 Nbr: Pgs: 8756-64
  Associated Grant: Novel I3C Regulated Cell Cycle Factor in Breast Cancer Cells
 
Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.
  Periodical: Nutrition and Cancer
  Author(s): Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF.
  Yr: 2004 Vol: 50 Nbr: 2 Pgs: 161-7
  Associated Grant: Dietary Indole Effect on Estrogen Urinary Metabolites
 
Indole-3-carbinol inhibits CDK6 expression in human MCF-7 breast cancer cells by disrupting Sp1 transcription factor interactions with a composite element in the CDK6 gene promoter.
  Periodical: Journal of Biological Chemistry
  Author(s): Cram EJ, Liu BD, Bjeldanes LF, Firestone GL.
  Yr: 2001 Vol: 276 Nbr: 25 Pgs: 22332-40
  Associated Grant: Indole Derivatives as Novel Breast Cancer Therapeutics
 
The major cyclic trimeric product of indole-3-carbinol is a strong agonist of the estrogen receptor signaling pathway.
  Periodical: Biochemistry
  Author(s): Riby JE, Feng C, Chang YC, Schaldach CM, Firestone GL, Bjeldanes LF
  Yr: 2000 Vol: 39 Nbr: 5 Pgs: 910-918
  Associated Grant: Indole Derivatives as Novel Breast Cancer Therapeutics
 
Indole-3-carbinol and Tamoxifen Cooperate to Arrest the Cell Cycle of MCF-7 Human Breast Cancer Cells
  Periodical: Cancer Research
  Author(s): Cover CM, Hsieh SJ, Cram EJ, Hong C, Riby JE, Beljanes LF, and Firestone GL
  Yr: 1999 Vol: 59 Nbr: Pgs: 1244-1251
  Associated Grant: Dietary Indole Inhibition of Breast Cancer
 
Indole-3-carbinol Inhibits the Expresion of Cycli-dependent Kinase-6 and Induces a G1 Cell Cycle Arrest of Human Breast Cancer Cells Independent of Estrogen Receptor Signaling
  Periodical: Journal of Biological Chemistry
  Author(s): Cover CM, Hsieh SJ, Tran SH, Halladen G, Kim GS, Bjeldanes LF, and Firestone GL
  Yr: 1998 Vol: 273 Nbr: 7 Pgs: 3838-3847
  Associated Grant: Dietary Indole Inhibition of Breast Cancer