Daniel Donoghue, Ph.D.

University of California, San Diego
email: ddonoghue@ucsd.edu

Grants

FGFR2 Signaling in Human Breast Cancer Cells 2008 (Cycle 14)
IDEA (Innovative, Developmental, and Exploratory Awards) 14IB-0065 $100,000
Mechanisms of Aberrant Cell Growth in Breast Cancer 1995 (Cycle I)
Research Project Awards 1RB-0318 $276,643


The atypical CDK activator Spy1 regulates the intrinsic DNA damage response and is dependent upon p53 to inhibit apoptosis.
  Periodical: Cell Cycle
  Author(s): McAndrew CW, Gastwirt RF, Donoghue DJ
  Yr: 2009 Vol: 8 Nbr: 1 Pgs: 66-75
  Associated Grant: FGFR2 Signaling in Human Breast Cancer Cells
 
Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase.
  Periodical: Molecular Biology of the Cell
  Author(s): Bell CA, Tynan JA, Hart KC, Meyer AN, Robertson SC, Donoghue DJ.
  Yr: 2000 Vol: 11 Nbr: 10 Pgs: 3589-99
  Associated Grant: Mechanisms of Aberrant Cell Growth in Breast Cancer
 
Activating mutations in th extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Robertson SC, Meyer AN, Hart KC, Galvin BD, Webster MK and Donoghue DJ
  Yr: 1998 Vol: 95 Nbr: 1 Pgs: 4567-4572
  Associated Grant: Mechanisms of Aberrant Cell Growth in Breast Cancer
 
Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain
  Periodical: Molecular Biology of the Cell
  Author(s): Webster MK, and Donoghue DJ
  Yr: 1997 Vol: 17 Nbr: 10 Pgs: 5739-5747
  Associated Grant: Mechanisms of Aberrant Cell Growth in Breast Cancer
 
Transmembrane domain sequence requirements for activation of the p185-c-neu receptor tyrosine kinase
  Periodical: Journal of Cell Biology
  Author(s): Chen LI, Webster MK, Meyer AN, and Donoghue DJ
  Yr: 1997 Vol: 137 Nbr: 3 Pgs: 619-631
  Associated Grant: Mechanisms of Aberrant Cell Growth in Breast Cancer