John Reed, M.D., Ph.D.

The Burnham Institute for Medical Research
email: jreed@burnham.org

Grants

PPAR Modulators as Apoptosis Sensitizers for Breast Cancer 2002 (Cycle VIII)
STEP Award 8WB-0079 $456,924
Role of Gamma-catenin in a Breast Cancer Mouse Model 1998 (Cycle IV)
IDEAS II 4JB-0061 $290,363
Immune responses to breast cancers: function of TRAF protein 1996 (Cycle II)
Research Project Awards 2RB-0215 $284,581
Bax gene expression in breast cancer 1995 (Cycle I)
Research Project Awards 1RB-0093 $559,057


An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis.
  Periodical: Journal of Biological Chemistry
  Author(s): Kim Y, Suh N, Sporn M, Reed JC.
  Yr: 2002 Vol: 277 Nbr: 25 Pgs: 22320-9
  Associated Grant: PPAR Modulators as Apoptosis Sensitizers for Breast Cancer
 
Siah, SIP, and Ebi collaborate in a novel pathway for b-catenin degradation linked to p53 responses
  Periodical: Molecular Cell
  Author(s): Matsuzawa SI, Reed JC
  Yr: 2001 Vol: 7 Nbr: 5 Pgs: 915-26
  Associated Grant: Role of Gamma-catenin in a Breast Cancer Mouse Model
 
SIP: a protein that bridges Siah-family E3 ubiquitin ligases to the SCF complex component Skp1.
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Matsuzawa S, and Reed JC
  Yr: 2000 Vol: 41 Nbr: Pgs: 3587
  Associated Grant: Role of Gamma-catenin in a Breast Cancer Mouse Model
 
p21-Activated Kinase 1 Phosphorylates the Death Agonist Bad and Protects Cells from Apoptosis
  Periodical: Molecular Biology of the Cell
  Author(s): Schurmann A, Mooney AF, Sanders LC, Sells MA, Wang HG, Reed JC, Bokoch GM
  Yr: 2000 Vol: 20 Nbr: 2 Pgs: 453-461
  Associated Grant: Role of Gamma-catenin in a Breast Cancer Mouse Model
 
Identification of novel human F-box proteins
  Periodical: Proceedings of the American Association for Cancer Research
  Author(s): Matsuzawa S, Reed JC
  Yr: 2000 Vol: 41 Nbr: Pgs: 3586
  Associated Grant: Role of Gamma-catenin in a Breast Cancer Mouse Model
 
p53 Suppressed the c-Myb-induced Activation of heat Shock Transcription Factor 3
  Periodical: Journal of Biological Chemistry
  Author(s): Tanikawa J, Ichikawa-Iwata E, et al.
  Yr: 2000 Vol: 275 Nbr: 20 Pgs: 15578-15585
  Associated Grant: Role of Gamma-catenin in a Breast Cancer Mouse Model
 
In vivo patterns of BVL-2 family protein expression in breast carcinomas in relation to apoptotic index and patients' menstrual status
  Periodical: Journal Pathologiques
  Author(s): Rochaix P, Voigt J-J, Krajewski S, Reed JC, Bonnet F, and Brousset P
  Yr: 1999 Vol: 187 Nbr: 4 Pgs: 410-415
  Associated Grant: Bax gene expression in breast cancer
 
Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7
  Periodical: Cancer Research
  Author(s): Piche A, Grim J, Rancourt C, Gomez-Navarro J, ReedJC, and Curiel DT
  Yr: 1998 Vol: 58 Nbr: 10 Pgs: 2134-2140
  Associated Grant: Bax gene expression in breast cancer
 
Bax directly induces release of cytochrome c from isolated mitochondria
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Jurgensmeier JM, Xie Z, Deveraux Q, Ellergy L, Bredesen D, and Reed JC
  Yr: 1998 Vol: 95 Nbr: Pgs: 4997-5002
  Associated Grant: Bax gene expression in breast cancer
 
Immunohistochemical analysis of bcl-2, bax, mcl-1and bcl-X expression in ovarian surface epitelial tumors
  Periodical: International Journal of Gynecol Pathol
  Author(s): Wehrli BM, Krajewski S, Gascoyne RD , Reed JC, and Gilks CB
  Yr: 1998 Vol: 17 Nbr: 3 Pgs: 255-260
  Associated Grant: Bax gene expression in breast cancer
 
The thiol crosslinking agent diamide overcomes the apoptosis-inhibitory effect of Bcl-2 by enforcing mitochondrial permeability transition
  Periodical: Oncogene
  Author(s): Zamzami N, Marzo I, Susin SA, Brenner C, Larochette N, Marchetti P, and Reed J, et al
  Yr: 1998 Vol: 16 Nbr: 8 Pgs: 1055-63
  Associated Grant: Bax gene expression in breast cancer
 
Cytoprotection by Bcl-2 requires the pore-forming alpha5 and alpha6 helices
  Periodical: Journal of Biological Chemistry
  Author(s): Matsuyama S, Schendel SL, Xie Z, and Reed JC
  Yr: 1998 Vol: 273 Nbr: 47 Pgs: 30995-31001
  Associated Grant: Bax gene expression in breast cancer
 
Expression of multiple apoptosis-regulatory genes in human breast cancer cell lines and primary tumors
  Periodical: Breast Cancer Research and Treatment
  Author(s): Zapata JM, Krajewska M, Krajewski S, Huang R-P, Takayama S, and Reed JC, et al
  Yr: 1998 Vol: 47 Nbr: Pgs: 129-140
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
Differences in susceptibility to tumor necrosis factor alpha-induced apoptosis among MCF-7 breast cancer cell variants
  Periodical: Cancer Research
  Author(s): Burow ME, Weldon CB, Tang Y, Navar G, Hammond T, Krajewski S, and Reed JC, et al
  Yr: 1998 Vol: 58 Nbr: 21 Pgs: 4940-4946
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
Granzyme release and caspase activation in human T-lymphocyts
  Periodical: Journal of Biological Chemistry
  Author(s): Zapata JM, Takahashi R, Salvesen GS, and Reed JC
  Yr: 1998 Vol: 273 Nbr: 12 Pgs: 6916-6920
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
  Periodical: Embo Journal
  Author(s): Deveraux Q, Roy N, Stennicke HR, Zhou Q, Srinivasula SM, and Reed JC at el
  Yr: 1998 Vol: 17 Nbr: 8 Pgs: 2215-2223
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
TRAF-4 expression in epithelial progenitor cells: Analysis in normal adult, fetal, and tumor tissues
  Periodical: American Journal of Pathology
  Author(s): Krajewska M, Krajewski S, Zapata JM, Van Arsdale TGascpume R, an Reed JC
  Yr: 1998 Vol: 152 Nbr: 6 Pgs: 1549-1561
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
Bax cleavage is mediated by calpain during drug-induced apoptosis
  Periodical: Oncogene
  Author(s): Wood DE, Thomas A, Devi LA, Berman Y, Beavis RC, and Reed JC
  Yr: 1998 Vol: 17 Nbr: 9 Pgs: 1069-1078
  Associated Grant: Bax gene expression in breast cancer
 
X-linked IAP is a direct inibitor of cell-death poteases
  Periodical: Nature
  Author(s): Deveraux Q, Takahashi R, Salvesen GS, and Reed JC
  Yr: 1997 Vol: 388 Nbr: 6639 Pgs: 300-4
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
Immunohistochemical analysis of in vivo patterns of TRAF-3 expression, a member of the TNF receptor-associated factor family
  Periodical: Journal of Immunology
  Author(s): Krajewski S, Zapata JM, Krajewksa M, VanArsdale T,Shabaik A, and Reed JC, et al
  Yr: 1997 Vol: 159 Nbr: Pgs: 5841-5852
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
  Periodical: Embo Journal
  Author(s): Roy N, Deveraux QL, Takahashi R, Salvesen GS and Reed JC
  Yr: 1997 Vol: 16 Nbr: 23 Pgs: 6914-6925
  Associated Grant: Immune responses to breast cancers: function of TRAF protein
 
Dissociation between cell cycle arrest and apoptosis can occur in Li-Fraumeni cells heterozygous for p53 gene mutations
  Periodical: Oncogene
  Author(s): Delia D, Goi K, Mizutani S, Yamada T, Aiello A, Fontanella E, and Reed JC, et al
  Yr: 1997 Vol: 14 Nbr: Pgs: 2137-2147
  Associated Grant: Bax gene expression in breast cancer
 
Analysis of Bax and Bcl-2 expression in p53-immunopositive breast cancers
  Periodical: Clinical Cancer Research
  Author(s): Krajewki S, Edgerton S, Moore II DH, Krajewska M, and Reed JC
  Yr: 1997 Vol: 3 Nbr: Pgs: 199-208
  Associated Grant: Bax gene expression in breast cancer
 
Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer Mcf-7 cells
  Periodical: Breast Cancer Research and Treatment
  Author(s): Huang Y, Ray S, Reed JC, Ibrado AM, Tang C, Nawabi A, Bhalla K
  Yr: 1997 Vol: 42 Nbr: Pgs: 73-81
  Associated Grant: Bax gene expression in breast cancer
 
Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis
  Periodical: Development
  Author(s): Humphreys RC, Krajewska M, Krnacik S, Jaeger R, Weiher H, Krajewski S, Reed JC, Rosen JM
  Yr: 1996 Vol: 122 Nbr: 12 Pgs: 4013-22
  Associated Grant: Bax gene expression in breast cancer
 
Structure-function comparisons of the proapoptoticprotein bax in yeast and mammalian cells
  Periodical: Molecular and Cellular Biology
  Author(s): Zha H, Fisk HA, Yaffe MP, Mahajan N, Herman B, and Reed JC
  Yr: 1996 Vol: 16 Nbr: 11 Pgs: 6494-508
  Associated Grant: Bax gene expression in breast cancer
 
Balancing cell life and death: Bax, apoptosis, and breast cancer
  Periodical: Journal of Clinical Investigation
  Author(s): Reed JC
  Yr: 1996 Vol: 97 Nbr: Pgs: 2403-2404
  Associated Grant: Bax gene expression in breast cancer