Pierre-Yves Desprez, Ph.D.

California Pacific Medical Center Research Institute
email: pydesprez@cpmcri.org

Grants

Role of Id-2 in Breast Cancer and its Relationship to Id-1 2001 (Cycle VII)
STEP Award 7WB-0026 $296,531
Id-1 Expression During Breast Cancer Progression 1999 (Cycle V)
IDEA (Innovative, Developmental, and Exploratory Awards) 5IB-0111 $78,031
Novel Breast Cancer Epithelial Cell Metalloproteinase 1997 (Cycle III)
IDEA (Innovative, Developmental, and Exploratory Awards) 3IB-0123 $193,995
The Invasive Nature of Epithelial Breast Cancer Cells 1995 (Cycle I)
New Investigator 1KB-0274 $105,837
The Invasive Nature of Epithelial Breast Cancer Cells 1995 (Cycle I)
New Investigator 1KB-0274A $269,852


Reduction of human metastatic breast cancer cell aggressiveness on introduction of either form a or B of the progesterone receptor and then treatment with progestins.
  Periodical: Cancer Research
  Author(s): Sumida T, Itahana Y, Hamakawa H, Desprez PY
  Yr: 2004 Vol: 64 Nbr: 21 Pgs: 7886-7892
  Associated Grant: Role of Id-2 in Breast Cancer and its Relationship to Id-1
 
Id genes and proteins as promising targets in cancer therapy.
  Periodical: Trends in Molecular Medicine
  Author(s): Fong S, Debs RJ, Desprez PY
  Yr: 2004 Vol: 10 Nbr: 8 Pgs: 387-392
  Associated Grant: Role of Id-2 in Breast Cancer and its Relationship to Id-1
 
Id proteins in epithelial cells.
  Periodical: Experimental Cell Research
  Author(s): Coppe JP, Smith AP, Desprez PY
  Yr: 2003 Vol: 285 Nbr: 1 Pgs: 131-145
  Associated Grant: Role of Id-2 in Breast Cancer and its Relationship to Id-1
 
Helix-loop-helix proteins in mammary gland development and breast cancer.
  Periodical: Journal of Mammary Gland Biology and Neoplasia
  Author(s): Desprez PY, Sumida T, Coppe JP
  Yr: 2003 Vol: 8 Nbr: 2 Pgs: 225-239
  Associated Grant: Role of Id-2 in Breast Cancer and its Relationship to Id-1
 
Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells.
  Periodical: Cancer Research
  Author(s): Itahana Y, Singh J, Sumida T, Coppe JP, Parrinello S, Bennington JL, Desprez PY
  Yr: 2003 Vol: 63 Nbr: 21 Pgs: 7098-7105
  Associated Grant: Role of Id-2 in Breast Cancer and its Relationship to Id-1
 
Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Fong S, Itahana Y, Sumida T, Singh J, Coppe JP, Liu Y, Richards PC, Bennington JL, Lee NM,
  Yr: 2003 Vol: 100 Nbr: 23 Pgs: 13543-13548
  Associated Grant: Role of Id-2 in Breast Cancer and its Relationship to Id-1
 
Molecular cloning and characterization of a zinc finger protein involved in Id-1-stimulated mammary epithelial cell growth.
  Periodical: Journal of Biological Chemistry
  Author(s): Singh J, Itahana Y, Parrinello S, Murata K, Desprez PY.
  Yr: 2001 Vol: 276 Nbr: 13 Pgs: 11852-11858
  Associated Grant: Novel Breast Cancer Epithelial Cell Metalloproteinase
 
A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells
  Periodical: Cancer Research
  Author(s): Lin CQ, Singh J, Murata K, Itahana Y, Parrinello S, Liang SH, Gillett CE, Campisi J, et al
  Yr: 2000 Vol: 60 Nbr: 5 Pgs: 1332-1340
  Associated Grant: The Invasive Nature of Epithelial Breast Cancer Cells
 
Id-1, ITF-2 and Id-2 comprise a network of helix-loop-helix proteins that regulate mammary epithelial cell proliferation, differentiation and apoptosis. Journal of Bio;ogical Chemistry, 276, 39213-39219 (2001).
  Periodical: Cancer Research
  Author(s): S.Parrinello, C.Q.Lin, K.Murata, Y.Itahana, J.Singh, A.Krtolica, J.Campisi, P.Y.Desprez
  Yr: 2000 Vol: 60 Nbr: 5 Pgs: 1332-40
  Associated Grant: The Invasive Nature of Epithelial Breast Cancer Cells
 
A novel pathway for mammary epithelial cell invasion induced by the helix-loop-helix protein Id-1
  Periodical: Molecular and Cellular Biology
  Author(s): Desprez P-Y, Lin CQ, Thomasset N, Sympson C, Bissell MJ, and Campisi J
  Yr: 1998 Vol: 18 Nbr: 8 Pgs: 4577-88
  Associated Grant: The Invasive Nature of Epithelial Breast Cancer Cells