Shiuan Chen, Ph.D.

Beckman Research Institute of the City of Hope
email: schen@coh.org

Grants

Biologically relevant screening of endocrine disruptors 2011 (Cycle 17)
Request for Proposals 17UB-8701 $1,512,000
Grape Seed as Aromatase Inhibitor for Breast Cancer Risk 2004 (Cycle 10)
TRC (Translational Research Collaboration) Pilot Awards 10DB-0011 $0
Breast Cancer Prevention with Phytochemicals in Mushrooms 2004 (Cycle 10)
RFA (Request for Applications) 10PB-0140 $759,667
Breast Cancer Prevention with Phytoestrogens in Grape Juice 1998 (Cycle IV)
RFA (Request for Applications) 4PB-0115 $539,331
Control of Estrogen Production in Breast Cancer 1995 (Cycle I)
Research Project Awards 1RB-0118 $342,712


AroER tri-screenTM is a novel functional assay to estimate both estrogenic and estrogen precursor activity of chemicals or biological specimens
  Periodical: Breast Cancer Research and Treatment
  Author(s): Kanaya N., Nguyen D.M., Lu H., Wang Y-Z., Hsin L-Y., Petreas M., Nelson D., et al
  Yr: 2015 Vol: 151 Nbr: Pgs: 335-45
  Associated Grant: Biologically relevant screening of endocrine disruptors
 
AroER Tri-Screen Is a Biologically Relevant Assay for Endocrine Disrupting Chemicals Modulating the Activity of Aromatase and/or the Estrogen Receptor.
  Periodical: Toxicological Sciences
  Author(s): Chen S, Zhou D, Hsin LY, Kanaya N, Wong C, Yip R, Sakamuru S, Xia M, et al.
  Yr: 2014 Vol: 139 Nbr: 1 Pgs: 198-209
  Associated Grant: Biologically relevant screening of endocrine disruptors
 
Anti-aromatase activity of phytochemicals in white button mushrooms (Agaricus bisporus)
  Periodical: Cancer Research
  Author(s): Chen, S., Oh, S.-R., Phung, S., Hur, G., Ye, J.-J., Kwok, S.L., Shrode, G.E., et al.
  Yr: 2006 Vol: 66 Nbr: Pgs: 12026-34
  Associated Grant: Breast Cancer Prevention with Phytochemicals in Mushrooms
 
Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression.
  Periodical: Cancer Research
  Author(s): Kijima, I., Phung, S., Hur, G., Kwok, S.-L. and Chen, S.
  Yr: 2006 Vol: 66 Nbr: Pgs: 5960-7
  Associated Grant: Breast Cancer Prevention with Phytoestrogens in Grape Juice
 
Resveratrol suppresses aromatase at the levels of enzyme activity and mRNA expression.
  Periodical: Toxicological Sciences
  Author(s): Wang, Y., Chan, F. L., Chen, S. and Leung, L. K.
  Yr: 2006 Vol: 92 Nbr: Pgs: 71-7
  Associated Grant: Breast Cancer Prevention with Phytoestrogens in Grape Juice
 
Suppression of Estrogen Biosynthesis by Procyanidin Dimers in Red Wine and Grape Seeds
  Periodical: Cancer Research
  Author(s): Eng ET, Ye J, Williams D, Phung, S, et al
  Yr: 2003 Vol: 63 Nbr: Pgs: 8516-8522
  Associated Grant: Breast Cancer Prevention with Phytoestrogens in Grape Juice
 
Prevention and treatment of breast cancer by suppressing aromatase activity and expression
  Periodical: Annals of the New York Academy of Sciences
  Author(s): Chen S, Zhou D, Okubo T, Kao YC, Eng ET, Grube B, Kwon A, Yang C, Yu B
  Yr: 2002 Vol: 963 Nbr: Pgs: 229-38
  Associated Grant: Breast Cancer Prevention with Phytoestrogens in Grape Juice
 
Suppression of aromatase (estrogen synthetase) by red wine phytochemicals.
  Periodical: Breast Cancer Research and Treatment
  Author(s): ET Eng, D Williams, U Mandava, N Kirma, RR Tekmal, and S Chen.
  Yr: 2001 Vol: 67 Nbr: 2 Pgs: 133-46
  Associated Grant: Breast Cancer Prevention with Phytoestrogens in Grape Juice
 
Identification and characterization of a cAMP-responsive element in the region upstream from promoter 1.3 of the human aromatase gene.
  Periodical: Archives of Biochemistry and Biophysics
  Author(s): Zhou D, Chen S
  Yr: 1999 Vol: 371 Nbr: 2 Pgs: 179-90
  Associated Grant: Control of Estrogen Production in Breast Cancer
 
Aromatase and breast cancer
  Periodical: Frontiers in Bioscience
  Author(s): Chen S
  Yr: 1998 Vol: 3 Nbr: Pgs: 922-933
  Associated Grant: Control of Estrogen Production in Breast Cancer
 
Characterization of a sliencer element in the human aromatase gene
  Periodical: Archives of Biochemistry and Biophysics
  Author(s): Zhou D, and Chen S
  Yr: 1998 Vol: 353 Nbr: Pgs: 213-220
  Associated Grant: Control of Estrogen Production in Breast Cancer
 
Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells
  Periodical: Journal of Steroid Biochemistry and Molecular Biology
  Author(s): Zhou D, Zhou C, and Chen S
  Yr: 1997 Vol: 61 Nbr: Pgs: 273-280
  Associated Grant: Control of Estrogen Production in Breast Cancer
 
Identification of a promoter that controls aromatase expression in human breast cancer and adipose stromal cells
  Periodical: Journal of Biological Chemistry
  Author(s): Zhou D, Clarke P, Wang J, Chen S
  Yr: 1996 Vol: 271 Nbr: 25 Pgs: 15191-15202
  Associated Grant: Control of Estrogen Production in Breast Cancer