Benjamin Cravatt, Ph.D.

Scripps Research Institute
email: cravatt@scripps.edu

Grants

Profiling Enzyme Activities in Human Breast Cancer 2004 (Cycle 10)
TRC (Translational Research Collaboration) Full Research Awards 10EB-0086 $464,906
Profiling Enzyme Activities in Models of Human Breast Cancer 2002 (Cycle VIII)
STEP Award 8WB-0016 $369,508
Profiling Serine Protease Activities in Breast Cancer 2000 (Cycle VI)
IDEAS II 6JB-0091 $265,950


A streamlined platform for high-content functional proteomics of primary human specimens.
  Periodical: Nature Methods
  Author(s): Jessani N, Niessen S, et al., Yates JR 3rd, Jeffrey SS, Cravatt BF.
  Yr: 2005 Vol: 2 Nbr: 9 Pgs: 691-7
  Associated Grant: Profiling Enzyme Activities in Human Breast Cancer
 
Profiling enzyme activities in vivo using click chemistry methods.
  Periodical: Chemistry and Biology
  Author(s): Speers AE, Cravatt BF.
  Yr: 2004 Vol: 11 Nbr: Pgs: 535-546
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Jessani N, Humphrey M, McDonald WH, Niessen S, Masuda K, Gangadharan B, Yates JR 3rd, Muel
  Yr: 2004 Vol: 101 Nbr: 38 Pgs: 13756-13761
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Microarray platform for profiling enzyme activities in complex proteomes.
  Periodical: Journal American Chemicaal Society
  Author(s): Sieber SA, Mondala TS, Head SR, Cravatt BF
  Yr: 2004 Vol: 126 Nbr: Pgs: 15640-15641
  Associated Grant: Profiling Enzyme Activities in Human Breast Cancer
 
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo.
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Jessani N, Humphrey M, et al , Yates JR 3rd, Mueller BM, Cravatt BF
  Yr: 2004 Vol: 101 Nbr: 38 Pgs: 13756-13761
  Associated Grant: Profiling Enzyme Activities in Human Breast Cancer
 
Activity-based protein profiling in vivo using a copper(l)-catalyzed [3+2] azide-alkyne cycloaddition
  Periodical: Journal of the American Chemistry Society
  Author(s): Speers AE, Adam GC, Cravatt BF
  Yr: 2003 Vol: 125 Nbr: Pgs: 4686-4687
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Jessani N, Liu Y, Humphrey M, Cravatt BF
  Yr: 2002 Vol: 99 Nbr: 16 Pgs: 10335-40
  Associated Grant: Profiling Serine Protease Activities in Breast Cancer
 
Chemical strategies for functional proteomics
  Periodical: Molecular and Cellular Proteomics
  Author(s): Adam GC, Sorense EJ, Cravatt BF
  Yr: 2002 Vol: 1 Nbr: 10 Pgs: 781-90
  Associated Grant: Profiling Serine Protease Activities in Breast Cancer
 
Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes
  Periodical: Molecular and Cellular Proteomics
  Author(s): Adam GC, Sorensen EJ, Cravatt BF
  Yr: 2002 Vol: 1 Nbr: 10 Pgs: 828-35
  Associated Grant: Profiling Serine Protease Activities in Breast Cancer
 
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness
  Periodical: Proceedings of the National Academy of Sciences of the United States of America
  Author(s): Jessani N, Liu Y, Humphrey M, Cravatt BF
  Yr: 2002 Vol: 99 Nbr: Pgs: 10335-10340
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype
  Periodical: Nature Biotechnology
  Author(s): Adam GC, Sorensen EJ, Cravatt BF
  Yr: 2002 Vol: 20 Nbr: 8 Pgs: 805-809
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Trifunctional chemical probes for the consolidated detection and identification of enzyme activities in complex proteomes
  Periodical: Molecular and Cellular Proteomics
  Author(s): Adam GC, Sorensen EJ, Cravatt BF
  Yr: 2002 Vol: 1 Nbr: Pgs: 828-835
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Chemical strategies for functional proteomics
  Periodical: Molecular and Cellular Proteomics
  Author(s): Adam GC, Sorensen EJ, Cravatt BF
  Yr: 2002 Vol: 1 Nbr: 10 Pgs: 781-790
  Associated Grant: Profiling Enzyme Activities in Models of Human Breast Cancer
 
Profiling serine hydrolase activities in complex proteomes.
  Periodical: Biochemistry
  Author(s): Kidd D, Liu Y, and Cravatt BF
  Yr: 2001 Vol: 40 Nbr: Pgs: 4005-4015
  Associated Grant: Profiling Serine Protease Activities in Breast Cancer