4th Inter. Symp. on the Intraductal Approach to the Breast

Institution: Dr. Susan Love Research Foundation
Investigator(s): Susan Love, M.D., M.B.A. -
Award Cycle: 2005 (Cycle 11) Grant #: 11MB-0001 Award: $25,000
Award Type: Joining Forces Conference Award
Research Priorities
Etiology and Prevention>Etiology: the role of environment and lifestyle

Initial Award Abstract (2005)
The Dr. Susan Love Research Foundation is dedicated to the eradication of breast cancer. The ability to access the lining of the milk ducts where breast cancer starts has provided researchers with the extraordinary opportunity to develop a new model for risk detection and prevention of breast cancer, much like the Pap smear for cervical cancer. In an effort to nurture this growing field of intraductal research, the Foundation initiated a biennial international conference. The goal of the meeting is to: (1) facilitate collaboration among researchers, (2) provide history and context to new researchers, (3) achieve consensus on the clinical utility of the technique, and (4) grant pilot money to those wanting to explore this approach. The growth of the conference mirrors the growth of the field from 30 attendees in 1999 to 120 in 2003.

The CBCRP Joining Forces Conference Award will help support the 4th International Symposium on the Intraductal Approach to the Breast on March 10-13, 2005. We anticipate more than 150 clinicians, researchers, and advocates from throughout the world will meet in Santa Barbara, CA. The purpose of the conference is to: (1) gather experienced and new researchers together to describe their experiences, to share their findings and to stimulate ideas related to the intraductal approach; (2) foster multidisciplinary and cross disciplinary collaborations; 3) provide pilot grants to further stimulate new research using the intraductal approach; (4) develop a consensus statement on the current clinical utility of this approach; and (5) foster a partnerships between the individual donors of research funds, advocates and researchers.

Experienced researchers will start the conference with a short history of the intraductal approach followed by presentations from current researchers who have either published or are funded to do research in the field. General topics will include: (1) biomarkers, (3) proteomics, (3) genetic analysis of breast ductal fluid, (4) technical aspects of fluid analysis, (5) clinical applications of ductal lavage, (6) anatomy and physiology of the normal breast, and (7) intraductal therapy. A debate on the current clinical utility of ductal lavage will serve as the basis for a consensus report which will be issued from the conference. In addition, pilot grant applicants will present their proposals before the whole conference in order to gain from the collective wisdom of the participants and the critical evaluation by the peer review committee.

Scientific culture often fosters competition rather than collaboration. This conference is an attempt to counteract that prevailing spirit. All attendees sign a non-disclosure agreement attesting to the fact that they will respect the proprietary nature of any data that is shared. This fosters a unique open attitude, which leads to speculation and hypothesis sharing rarely seen in professional meetings. Researchers who have been in the field since the 1970s participate fully, allowing the newer entrants to avoid re-exploring previously unrewarding approaches. Collaborations are fostered and nurtured in this still small community of scientists and clinicians. The 2005 Symposium will include a clinical debate on the current clinical utility of ductal lavage, which will serve as the basis of a consensus statement to be submitted for publication. Finally, grant applicants present their concepts to the whole meeting, and benefit from the feedback of the larger community as well as the opportunity for collaboration. In order to accelerate,the research process, peer review takes place immediately and grants are awarded at the end of the conference.

Advocates are specifically invited from national and local groups (Y-ME, Young Survival Coalition, BCA, NBCC, LABCA, Women of Color, and CABCO). The Foundation and CBCRP funding will provide scholarships for a minimum of four advocates. Two advocates will be asked to participate in the peer review and two additional advocates will participate in the clinical debate. The conference proceedings will be posted on the SusanLoveMD.org website to ensure access for the advocacy community. On the second night of the conference a dinner is held where donors (large and small) for the research fund are invited to come and meet with the scientists they are funding. This direct connection between the source of the funding and the user of the funds is important in increasing the accountability of the scientists and the enthusiasm of the donors, and creating a unique research community.

Final Report (2005)
The 4th International Symposium on the Intraductal Approach to Breast Cancer on March 10-13, 2005 hosted by the Dr. Susan Love Research Foundation brought together more than 100 researchers, clinicians, and patient advocates from all over the globe, country and many from California to discuss the current status and future of the intraductal approach to understating the breast.

In addition to the 38 talks by invited speakers, 11 individuals presented pilot research projects for potential funding by the Foundation. The researchers that we have encouraged and supported come from a variety of scientific backgrounds, including: both basic and clinical sciences, including medical oncology, internal medicine, surgery, radiology, biochemistry, pathology, endocrinology, epidemiology, and biostatistics. As a result of the funding from the CBCRP, research is being conducted throughout the United States, Australia, China, England, and Italy.

The conference brought all of these individuals together to: (1) describe their experiences, and share research or clinical findings, (2) develop multidisciplinary and cross-disciplinary collaborations, (3) award new pilot grants to further stimulate research using the intraductal approach, (4) develop a consensus statement of the current clinical utility of the intraductal approach, and (5) foster a partnership between the individual donors of research funds, advocates and researchers.

During the conference, a multidisciplinary peer review committee met, discussed the 11 pilot grant presentations, and made decisions about the awards to be distributed. As a result, the Dr. Susan Love Research Foundation provided a total of $65,000 to 7 researchers across the country and in Italy.

New this year, the Foundation hosted a Public Panel discussion on Saturday, March 12. This panel consisted of experts form medical oncology, surgery, pathology and basic science. The panel provided community members with the opportunity to learn about the intraductal approach to breast cancer, research currently going on in the field of breast cancer, and to ask questions about current breast cancer treatment options. After the formal panel presentation, the audience had the opportunity to ask questions about ductal lavage and breast cancer care. Several topics were raised from survival differences for African-American women, to the use of Herceptin, and breast cancer risk factors. Approximately 35 men and women attended the panel.

Research using the intraductal approach is truly innovative and could ultimately lead us to the eradication of breast cancer. This conference directly helped develop multidisciplinary and cross-disciplinary collaborations among researchers, provide pilot grants to support new research in a variety of projects, and educate the public and advocates about the state of breast cancer research and the possibilities of the future.

The Fourth International Symposium on the Intraductal Approach to Breast Cancer, Santa Barbara, California, 10-13 March 2005.
Periodical:Breast Cancer Research
Index Medicus: Breast Cancer Res
Authors: King BL, Love SM, Rochman S, Kim JA.
Yr: 2005 Vol: 7 Nbr: 5 Abs: Pg:198-204